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Chemically, it is defined as 5,6-dihydro-9,10-dimethoxybenzo[ g ]-1,3-benzodioxolo [5,6- a ]quinolizinium, with the formula C 20 H 18 NO 4 + and a molecular weight of 336.36 g/mol, although its chloride salt form (C 20 H 17 NO 4 HCl·2H 2 O, MW: 407.646 g/mol) is more commonly utilized
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The importance of mitochondrial superoxide in mediating APAP hepatotoxicity is further illustrated by the significant exacerbation of liver injury in mice with a partial deficiency of manganese superoxide dismutase (SOD2)34,35, which would usually scavenge superoxide within the mitochondria
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