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An ephrin receptor tyrosine kinase, EphA2, which is largely expressed in various tumor cells, interacts with and phosphorylates claudin-4 at Y208, leading to an increase in paracellular permeability [66]
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Since scarring alopecia is seen as a permanent hair loss issue, there are challenges in assessing the use of JAK inhibitors for subtypes of alopecia outside of AA
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